作者
Sonja Mc De Zwarte, Rachel M Brouwer, Ingrid Agartz, Martin Alda, André Aleman, Kathryn I Alpert, Carrie E Bearden, Alessandro Bertolino, Catherine Bois, Aurora Bonvino, Elvira Bramon, Elizabeth EL Buimer, Wiepke Cahn, Dara M Cannon, Tyrone D Cannon, Xavier Caseras, Josefina Castro-Fornieles, Qiang Chen, Yoonho Chung, Elena De la Serna, Annabella Di Giorgio, Gaelle E Doucet, Mehmet Cagdas Eker, Susanne Erk, Scott C Fears, Sonya F Foley, Sophia Frangou, Andrew Frankland, Janice M Fullerton, David C Glahn, Vina M Goghari, Aaron L Goldman, Ali Saffet Gonul, Oliver Gruber, Lieuwe De Haan, Tomas Hajek, Emma L Hawkins, Andreas Heinz, Manon HJ Hillegers, Hilleke E Hulshoff Pol, Christina M Hultman, Martin Ingvar, Viktoria Johansson, Erik G Jönsson, Fergus Kane, Matthew J Kempton, Marinka MG Koenis, Miloslav Kopecek, Lydia Krabbendam, Bernd Krämer, Stephen M Lawrie, Rhoshel K Lenroot, Machteld Marcelis, Jan-Bernard C Marsman, Venkata S Mattay, Colm McDonald, Andreas Meyer-Lindenberg, Stijn Michielse, Philip B Mitchell, Dolores Moreno, Robin M Murray, Benson Mwangi, Pablo Najt, Emma Neilson, Jason Newport, Jim Van Os, Bronwyn Overs, Aysegul Ozerdem, Marco M Picchioni, Anja Richter, Gloria Roberts, Aybala Saricicek Aydogan, Peter R Schofield, Fatma Simsek, Jair C Soares, Gisela Sugranyes, Timothea Toulopoulou, Giulia Tronchin, Henrik Walter, Lei Wang, Daniel R Weinberger, Heather C Whalley, Nefize Yalin, Ole A Andreassen, Christopher RK Ching, Theo Gm Van Erp, Jessica A Turner, Neda Jahanshad, Paul M Thompson, René S Kahn, Neeltje EM van Haren
发表日期
2019/10/1
期刊
Biological psychiatry
卷号
86
期号
7
页码范围
545-556
出版商
Elsevier
简介
Background
Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.
Methods
We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the …
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SM De Zwarte, RM Brouwer, I Agartz, M Alda… - Biological psychiatry, 2019