作者
Anders M Fjell, Kristine Beate Walhovd, Timothy T Brown, Joshua M Kuperman, Yoonho Chung, Donald J Hagler Jr, Vijay Venkatraman, J Cooper Roddey, Matthew Erhart, Connor McCabe, Natacha Akshoomoff, David G Amaral, Cinnamon S Bloss, Ondrej Libiger, Burcu F Darst, Nicholas J Schork, BJ Casey, Linda Chang, Thomas M Ernst, Jeffrey R Gruen, Walter E Kaufmann, Tal Kenet, Jean Frazier, Sarah S Murray, Elizabeth R Sowell, Peter Van Zijl, Stewart Mostofsky, Terry L Jernigan, Anders M Dale, Terry L Jernigan, Connor McCabe, Linda Chang, Natacha Akshoomoff, Erik Newman, Anders M Dale, Thomas Ernst, Anders M Dale, Peter Van Zijl, Joshua Kuperman, Sarah Murray, Cinnamon Bloss, Nicholas J Schork, Mark Appelbaum, Anthony Gamst, Wesley Thompson, Hauke Bartsch, Terry L Jernigan, Anders M Dale, Natacha Akshoomoff, Linda Chang, Thomas Ernst, Brian Keating, David Amaral, Elizabeth Sowell, Walter Kaufmann, Peter Van Zijl, Stewart Mostofsky, BJ Casey, Erika J Ruberry, Alisa Powers, Bruce Rosen, Tal Kenet, Jean Frazier, David Kennedy, Jeffrey Gruen
发表日期
2012/11/27
期刊
Proceedings of the National Academy of Sciences
卷号
109
期号
48
页码范围
19620-19625
出版商
National Academy of Sciences
简介
Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4–21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This …
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AM Fjell, KB Walhovd, TT Brown, JM Kuperman… - Proceedings of the National Academy of Sciences, 2012