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²²²Rn concentration indoors was measured in 40 dwellings in the Obuasi municipality, a gold-mining town in the Ashanti Region of Ghana using the LR 115 type II strippable detectors for the two major seasons in Ghana, rainy and dry. The detectors were placed in the bed rooms of dwellers for 6 months each. Average indoor radon concentration varied from 63.9 to 364.9 Bqm⁻³ with a mean of 152.2 ± 10.9 Bqm⁻³ in the rainy season and 26.1–119.0 Bqm⁻³ with a mean of 50.5 ± 3.9 Bqm⁻³ in the dry season. The effective dose of 3.90 ± 0.3 mSvy⁻¹ for the rainy season and for the dry season, effective dose of 0.6 mSvy⁻¹ were recorded. The seasonal variation of ²²²Rn concentration indoors showed higher values in the rainy season than the dry season. A dependence was observed between the type of building materials used in building and the indoor radon level.