作者
Jia Geng, Kyunghoon Kim, Jianfei Zhang, Artur Escalada, Ramya Tunuguntla, Luis R. Comolli, Frances I. Allen, Anna V. Shnyrova, Kang Rae Cho, Dayannara Munoz, Y. Morris Wang, Costas P. Grigoropoulos, Caroline M. Ajo-Franklin, Vadim A. Frolov, Aleksandr Noy
发表日期
2014
期刊
Nature
卷号
514
页码范围
612--615
简介
There is much interest in developing synthetic analogues of biological membrane channels with high efficiency and exquisite selectivity for transporting ions and molecules. Bottom-up and top-down methods can produce nanopores of a size comparable to that of endogenous protein channels, but replicating their affinity and transport properties remains challenging. In principle, carbon nanotubes (CNTs) should be an ideal membrane channel platform: they exhibit excellent transport properties,,,, and their narrow hydrophobic inner pores mimic structural motifs typical of biological channels. Moreover, simulations predict that CNTs with a length comparable to the thickness of a lipid bilayer membrane can self-insert into the membrane,. Functionalized CNTs have indeed been found to penetrate lipid membranes and cell walls,, and short tubes have been forced into membranes to create sensors, yet membrane …
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