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The study was carried out to determine the phytochemical screening and antibacterial activities (% inhibition) of methanol stem bark extract of P. thonningii plant. Preliminary phytochemical screening revealed the presence (+) of alkaloids, tannins, saponins, flavonoids, phenols and steroids while terpenoids, glycoside and proteins were absent (-). The antibacterial activity (% inhibition) was determined using the modified broth dilution method. The result revealed that the extract significantly inhibited S. aureus, S. typhi and P. aeruginosa at lower concentrations (2-6 mg/ml) compared to Azithromycin which inhibited the pathogenic test organisms at the higher concentrations (8 and 10 mg/ml) respectively. The result also revealed that E. coli and B. cereus was significantly inhibited by Azithromycin compared to the extract. The study showed that the extract has vital phytochemicals and potent antibacterial activity. This findings support the use of the plant locally as herbal medicine for treating bacterial diseases.