作者
Brendan J Loftus, Eula Fung, Paola Roncaglia, Don Rowley, Paolo Amedeo, Dan Bruno, Jessica Vamathevan, Molly Miranda, Iain J Anderson, James A Fraser, Jonathan E Allen, Ian E Bosdet, Michael R Brent, Readman Chiu, Tamara L Doering, Maureen J Donlin, Cletus A D'Souza, Deborah S Fox, Viktoriya Grinberg, Jianmin Fu, Marilyn Fukushima, Brian J Haas, James C Huang, Guilhem Janbon, Steven JM Jones, Hean L Koo, Martin I Krzywinski, June K Kwon-Chung, Klaus B Lengeler, Rama Maiti, Marco A Marra, Robert E Marra, Carrie A Mathewson, Thomas G Mitchell, Mihaela Pertea, Florenta R Riggs, Steven L Salzberg, Jacqueline E Schein, Alla Shvartsbeyn, Heesun Shin, Martin Shumway, Charles A Specht, Bernard B Suh, Aaron Tenney, Terry R Utterback, Brian L Wickes, Jennifer R Wortman, Natasja H Wye, James W Kronstad, Jennifer K Lodge, Joseph Heitman, Ronald W Davis, Claire M Fraser, Richard W Hyman
发表日期
2005/2/25
期刊
Science
卷号
307
期号
5713
页码范围
1321-1324
出版商
American Association for the Advancement of Science
简介
Cryptococcus neoformans is a basidiomycetous yeast ubiquitous in the environment, a model for fungal pathogenesis, and an opportunistic human pathogen of global importance. We have sequenced its ∼20-megabase genome, which contains ∼6500 intron-rich gene structures and encodes a transcriptome abundant in alternatively spliced and antisense messages. The genome is rich in transposons, many of which cluster at candidate centromeric regions. The presence of these transposons may drive karyotype instability and phenotypic variation. C. neoformans encodes unique genes that may contribute to its unusual virulence properties, and comparison of two phenotypically distinct strains reveals variation in gene content in addition to sequence polymorphisms between the genomes.
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