作者
Heli T Viljakainen, Milja Väisänen, Virpi Kemi, Toni Rikkonen, Heikki Kröger, E Kalevi A Laitinen, Hannu Rita, Christel Lamberg‐Allardt
发表日期
2009/2/1
期刊
Journal of Bone and Mineral Research
卷号
24
期号
2
页码范围
346-352
出版商
John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
简介
Vitamin D is suggested to have a role in the coupling of bone resorption and formation. Compared with women, men are believed to have more stable bone remodeling, and thus, are considered less susceptible to the seasonal variation of calcitropic hormones. We examined whether seasonal variation exists in calcitropic hormones, bone remodeling markers, and BMD in healthy men. Furthermore, we determined which vitamin D intake is required to prevent this variation. Subjects (N = 48) were healthy white men 21–49 yr of age from the Helsinki area with a mean habitual dietary intake of vitamin D of 6.6 ± 5.1 (SD) μg/d. This was a 6‐mo double‐blinded vitamin D intervention study, in which subjects were allocated to three groups of 20 μg (800 IU), 10 μg (400 IU), or placebo. Fasting blood samplings were collected six times for analyses of serum (S‐)25(OH)D, iPTH, bone‐specific alkaline phosphatase (BALP …
引用总数
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