作者
Adithya Cattamanchi, Raymund B Dantes, John Z Metcalfe, Leah G Jarlsberg, Jennifer Grinsdale, L Masae Kawamura, Dennis Osmond, Philip C Hopewell, Payam Nahid
发表日期
2009/1/15
期刊
Clinical Infectious Diseases
卷号
48
期号
2
页码范围
179-185
出版商
The University of Chicago Press
简介
Background. Risk factors and treatment outcomes under program conditions for isoniazid (INH) monoresistant tuberculosis have not been well described.
Methods. Medical charts were retrospectively reviewed for all cases of culture-confirmed, INH-monoresistant tuberculosis (n=137) reported to the San Francisco Department of Public Health Tuberculosis Control Section from October 1992 through October 2005, and those cases were compared with a time-matched sample of drug-susceptible tuberculosis cases (n=274).
Results. In multivariate analysis, only a history of treatment for latent tuberculosis (odds ratio [OR], 3.1; 95% confidence interval [CI], 1.5 6.4; P=.003) or for active tuberculosis (OR, 2.7; 95% CI, 1.4 5.0; P=.002) were significantly associated with INH-monoresistant tuberculosis. Of the 119 patients who completed treatment, 49 (41 …
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