作者
Franco Rongioletti, Giulia Merlo, Elisa Cinotti, Valentina Fausti, Emanuele Cozzani, Bernard Cribier, Dieter Metze, Eduardo Calonje, Jean Kanitakis, Werner Kempf, Catherine M Stefanato, Eduardo Marinho, Aurora Parodi
发表日期
2013/7/1
期刊
Journal of the American Academy of Dermatology
卷号
69
期号
1
页码范围
66-72
出版商
Mosby
简介
BACKGROUND
Scleromyxedema is associated with a monoclonal gammopathy and other comorbidities. Its prognostic and therapeutic features are poorly documented because most reports deal with single cases or small series.
OBJECTIVE
We sought to describe the characteristics of patients with scleromyxedema regarding demographics, clinical characteristics, comorbidities, therapeutic interventions, and course.
METHODS
We conducted a retrospective and prospective multicenter study.
RESULTS
We identified 30 patients with scleromyxedema (17 men and 13 women). The mean age at diagnosis was 59 years. The mean delay between disease onset and diagnosis was 9 months. Monoclonal gammopathy was detected in 27 patients. Extracutaneous manifestations were present in 19 patients including neurologic (30%), rheumatologic (23.3%), and cardiac (20%) manifestations. Two patients developed …
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F Rongioletti, G Merlo, E Cinotti, V Fausti, E Cozzani… - Journal of the American Academy of Dermatology, 2013
