作者
Arnaud Dubois, Olivier Levecq, Hicham Azimani, David Siret, Anaïs Barut, Mariano Suppa, Véronique Del Marmol, Josep Malvehy, Elisa Cinotti, Pietro Rubegni, Jean-Luc Perrot
发表日期
2018/10/1
期刊
Journal of biomedical optics
卷号
23
期号
10
页码范围
106007-106007
出版商
Society of Photo-Optical Instrumentation Engineers
简介
An optical technique called line-field confocal optical coherence tomography (LC-OCT) is introduced for high-resolution, noninvasive imaging of human skin in vivo. LC-OCT combines the principles of time-domain optical coherence tomography and confocal microscopy with line illumination and detection using a broadband laser and a line-scan camera. LC-OCT measures the echo-time delay and amplitude of light backscattered from cutaneous microstructures through low-coherence interferometry associated with confocal spatial filtering. Multiple A-scans are acquired simultaneously while dynamically adjusting the focus. The resulting cross-sectional B-scan image is produced in real time at 10 frame / s. With an isotropic spatial resolution of ∼1 μm, the LC-OCT images reveal a comprehensive structural mapping of skin at the cellular level down to a depth of ∼500 μm. LC-OCT has been applied to …
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A Dubois, O Levecq, H Azimani, D Siret, A Barut… - Journal of biomedical optics, 2018