作者
Nitipong Permpalung, Veraprapas Kittipibul, Poemlarp Mekraksakit, Pattara Rattanawong, Saman Nematollahi, Sean X Zhang, Seema Mehta Steinke
发表日期
2021/10/1
来源
Transplantation
卷号
105
期号
10
页码范围
2291-2306
出版商
LWW
简介
Background.
There is no consensus guidance on when to reinitiate Pneumocystis jirovecii pneumonia (PJP) prophylaxis in solid organ transplant (SOT) recipients at increased risk. The 2019 American Society of Transplantation Infectious Diseases Community of Practice (AST IDCOP) guidelines suggested to continue or reinstitute PJP prophylaxis in those receiving intensified immunosuppression for graft rejection, cytomegalovirus (CMV) infection, higher dose of corticosteroids, or prolonged neutropenia.
Methods.
A literature search was conducted evaluating all literature from existence through April 22, 2020, using MEDLINE and EMBASE.(The International Prospective Register of Systematic Reviews registration number: CRD42019134204).
Results.
A total of 30 studies with 413 276 SOT recipients were included. The following factors were associated with PJP development: acute rejection (pooled odds ratio [pOR …
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