作者
Manse Kim, Abhishek Sahu, Gi Beom Kim, Gi Hoon Nam, Wooram Um, So Jin Shin, Yong Yeon Jeong, In-San Kim, Kwangmeyung Kim, Ick Chan Kwon, Giyoong Tae
发表日期
2018/1/10
期刊
Journal of Controlled Release
卷号
269
页码范围
337-346
出版商
Elsevier
简介
Atherosclerosis plaque is a major cause of cardiovascular diseases across the globe and a silent killer. There are no physical symptoms of the disease in its early stage and current diagnostic techniques cannot detect the small plaques effectively or safely. Plaques formed in blood vessels can cause serious clinical problems such as impaired blood flow or sudden death, regardless of their size. Thus, detecting early stage of plaques is especially more important to effectively reduce the risk of atherosclerosis. Nanoparticle based delivery systems are recognized as a promising option to fight against this disease, and various targeting ligands are typically used to improve their efficiency. So, the choice of appropriate targeting ligand is a crucial factor for optimal targeting efficiency. cRGD peptide and collagen IV targeting peptide, which binds with the αvβ3 integrin overexpressed in the neovasculature of the plaque and …
学术搜索中的文章
M Kim, A Sahu, GB Kim, GH Nam, W Um, SJ Shin… - Journal of Controlled Release, 2018