作者
Manse Kim, Claire E Johnson, Alan A Schmalstig, Ayano Annis, Sarah E Wessel, Brian Van Horn, Amanda Schauer, Agata A Exner, Jason E Stout, Angela Wahl, Miriam Braunstein, J Victor Garcia, Martina Kovarova
发表日期
2022/8/8
期刊
Nature communications
卷号
13
期号
1
页码范围
4455
出版商
Nature Publishing Group UK
简介
Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis (Mtb) and is a major cause of morbidity and mortality. Successful treatment requires strict adherence to drug regimens for prolonged periods of time. Long-acting (LA) delivery systems have the potential to improve adherence. Here, we show the development of LA injectable drug formulations of the anti-TB drug rifabutin made of biodegradable polymers and biocompatible solvents that solidifies after subcutaneous injection. Addition of amphiphilic compounds increases drug solubility, allowing to significantly increase formulation drug load. Solidified implants have organized microstructures that change with formulation composition. Higher drug load results in smaller pore size that alters implant erosion and allows sustained drug release. The translational relevance of these observations in BALB/c mice is demonstrated by (1 …
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M Kim, CE Johnson, AA Schmalstig, A Annis… - Nature communications, 2022