作者
Manse Kim, Youngmin Hwang, Giyoong Tae
发表日期
2016/12/1
期刊
International journal of biological macromolecules
卷号
93
页码范围
1603-1611
出版商
Elsevier
简介
The stability of tissue barrier in physiological condition is a key factor to isolate the damaged site from adjacent tissue for anti-tissue adhesion. Although pluronic or pluronic-hyaluronic acid (HA) hydrogel as an injectable formulation can prevent tissue adhesion at the injection site, the anti-tissue adhesion effect is limited due to its poor stability. Herein, we prepared tissue barrier formulations composed of pluronic F127 (F127) and HA mixture (F127-HA) and the effect of the addition of poly(γ-glutamic acid) (PGA) was characterized. All of F127, HA, and F127-HA mixture showed the poor in vitro residence stability less than 3 days. However, by adding PGA into F127-HA mixture, their stability was significantly enhanced by the control of the molecular weight and concentration of PGA. Thus, F127-HA with 10 wt% PGA (2000 kDa) showed the long-term stability over 10 days. Similarly, the enhanced stability of F127-HA …
学术搜索中的文章
M Kim, Y Hwang, G Tae - International journal of biological macromolecules, 2016