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Thermo-sensitive and injectable hydrogels have been widely investigated for drug delivery, tissue engineering, and other biomedical applications. Pluronic copolymers can form thermo-sensitive physical gel state, thus applicable for injectable hydrogels. However, they are not stable in vivo, showing a very fast dissolution, which limits their applications. We propose a novel Pluronic-based physical hydrogel with enhanced stability by simply adding a small quantity of graphene oxide (GO) which has a large surface area and can make strong interactions with Pluronic. Further carboxylated GO could act as a more efficient additive. The addition of GO increased the moduli of hydrogels, but more importantly, it enhanced the stability of Pluronic gel dramatically. The in vitro dissolution rate of Pluronic hydrogel could be systematically modulated by increasing GO content. Upon subcutaneous injection at a sol state, GO …