作者
William D Fraser, Justus Hofmeyr, Roberto Lede, Gilles Faron, Sophie Alexander, François Goffinet, Arne Ohlsson, Céline Goulet, Lucile Turcot-Lemay, Walter Prendiville, Sylvie Marcoux, Louise Laperrière, Chantal Roy, Stavros Petrou, Hai-Rong Xu, Bin Wei
发表日期
2005/9/1
期刊
New England Journal of Medicine
卷号
353
期号
9
页码范围
909-917
出版商
Massachusetts Medical Society
简介
Background
It is uncertain whether amnioinfusion (infusion of saline into the amniotic cavity) in women who have thick meconium staining of the amniotic fluid reduces the risk of perinatal death, moderate or severe meconium aspiration syndrome, or both.
Methods
We performed a multicenter trial in which 1998 pregnant women in labor at 36 or more weeks of gestation who had thick meconium staining of the amniotic fluid were stratified according to the presence or absence of variable decelerations in fetal heart rate and then randomly assigned to amnioinfusion or to standard care. The composite primary outcome measure was perinatal death, moderate or severe meconium aspiration syndrome, or both.
Results
Perinatal death, moderate or severe meconium aspiration syndrome, or both occurred in 44 infants (4.5 percent) of women in the amnioinfusion group and 35 infants (3.5 percent) of women in the …
引用总数
学术搜索中的文章
WD Fraser, J Hofmeyr, R Lede, G Faron, S Alexander… - New England Journal of Medicine, 2005