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Resistance to antibiotics is steadily increasing. Ceftaroline has a broad spectrum of activity against clinically relevant gram-positive strains including methicillin-resistant Staphylococcus aureus.

This systematic review was conducted to evaluate whether ceftaroline is effective and safe, leading to a lower rate of treatment failures than comparators.

Studies were included if they were comparing the efficacy and safety of ceftaroline with other antibiotics.

Using the search terms ‘ceftaroline’ or ‘ceftaroline fosamil’, a search strategy was developed. The efficacy endpoint was the rate of treatment failure, while the safety endpoint was the incidence of adverse events. Heterogeneity bias was estimated using the Q-test, and publication bias was estimated using Egger’s test. Null hypothesis was rejected if p value was less than 0.05.

Only 10 studies were included …