作者
Paul E Verweij, Bart JA Rijnders, Roger JM Brüggemann, Elie Azoulay, Matteo Bassetti, Stijn Blot, Thierry Calandra, Cornelius J Clancy, Oliver A Cornely, Tom Chiller, Pieter Depuydt, Daniele Roberto Giacobbe, Nico AF Janssen, Bart-Jan Kullberg, Katrien Lagrou, Cornelia Lass-Flörl, Russell E Lewis, Peter Wei-Lun Liu, Olivier Lortholary, Johan Maertens, Ignacio Martin-Loeches, M Hong Nguyen, Thomas F Patterson, Thomas R Rogers, Jeroen A Schouten, Isabel Spriet, Lore Vanderbeke, Joost Wauters, Frank L van de Veerdonk
发表日期
2020/8
来源
Intensive care medicine
卷号
46
期号
8
页码范围
1524-1535
出版商
Springer Berlin Heidelberg
简介
Purpose
Invasive pulmonary aspergillosis is increasingly reported in patients with influenza admitted to the intensive care unit (ICU). Classification of patients with influenza-associated pulmonary aspergillosis (IAPA) using the current definitions for invasive fungal diseases has proven difficult, and our aim was to develop case definitions for IAPA that can facilitate clinical studies.
Methods
A group of 29 international experts reviewed current insights into the epidemiology, diagnosis and management of IAPA and proposed a case definition of IAPA through a process of informal consensus.
Results
Since IAPA may develop in a wide range of hosts, an entry criterion was proposed and not host factors. The entry criterion was defined as a patient requiring ICU admission for respiratory distress with a positive influenza test temporally related to ICU admission. In addition, proven IAPA required histological evidence of …
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PE Verweij, BJA Rijnders, RJM Brüggemann… - Intensive care medicine, 2020