作者
Clarissa Consolandi, Silvia Turroni, Giacomo Emmi, Marco Severgnini, Jessica Fiori, Clelia Peano, Elena Biagi, Alessia Grassi, Simone Rampelli, Elena Silvestri, Manuela Centanni, Fabio Cianchi, Roberto Gotti, Lorenzo Emmi, Patrizia Brigidi, Nicola Bizzaro, Gianluca De Bellis, Domenico Prisco, Marco Candela, Mario M D'Elios
发表日期
2015/4/1
来源
Autoimmunity reviews
卷号
14
期号
4
页码范围
269-276
出版商
Elsevier
简介
Background and aims
Behçet syndrome is a systemic inflammatory condition characterized by muco-cutaneous and ocular manifestations, with central nervous system, vascular and/or gastro-intestinal involvement. The association of microbiota with Behçet syndrome has not been shown yet. Our work was aimed to compare the gut microbiota structure and the profiles of short-chain fatty acids production in Behçet syndrome patients and healthy control relatives.
Methods
Here, we compared the fecal microbiota of 22 patients with Behçet syndrome and that of 16 healthy co-habiting controls, sharing the same diet and lifestyle by pyrosequencing of the V3–V4 hypervariable regions of the 16 rDNA gene and biochemical analyses.
Results
Our analyses showed significant differences in gut microbiota between Behçet patients and healthy cohabitants. In particular we found that Behçet's patients were significantly depleted …
学术搜索中的文章
C Consolandi, S Turroni, G Emmi, M Severgnini, J Fiori… - Autoimmunity reviews, 2015