作者
Ahmed Moustafa, Weizhong Li, Ericka L Anderson, Emily HM Wong, Parambir S Dulai, William J Sandborn, William Biggs, Shibu Yooseph, Marcus B Jones, Craig J Venter, Karen E Nelson, John T Chang, Amalio Telenti, Brigid S Boland
发表日期
2018/1/1
期刊
Clinical and translational gastroenterology
卷号
9
期号
1
页码范围
e132
出版商
LWW
简介
OBJECTIVES:
Inflammatory bowel diseases (IBD), comprised of Crohn's disease (CD) and ulcerative colitis (UC), are characterized by a complex pathophysiology that is thought to result from an aberrant immune response to a dysbiotic luminal microbiota in genetically susceptible individuals. New technologies support the joint assessment of host-microbiome interaction.
METHODS:
Using whole genome sequencing and shotgun metagenomics, we studied the clinical features, host genome, and stool microbial metagenome of 85 IBD patients, and compared the results to 146 control individuals. Genetic risk scores, computed on 159 single nucleotide variants, and human leukocyte antigen (HLA) types differentiated IBD patients from healthy controls.
RESULTS:
Genetic risk was associated with the need for use of biologics in IBD and, modestly, with the composition of the gut microbiome. As compared with healthy …
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A Moustafa, W Li, EL Anderson, EHM Wong, PS Dulai… - Clinical and translational gastroenterology, 2018