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To determine whether previously described advanced blastocyst development and high implantation rates are confirmed in an expanded multicenter trial.

Retrospective review.

Two private assisted reproductive technology units. Patient(s): One hundred seventy-four patients who underwent blastocyst culture and transfer. Intervention(s): Culture of all pronucleate embryos in sequential media to the blastocyst stage (day 5) followed by ET. Main Outcome Measure(s): The number and percentage of blastocysts developed, implantation rates, pregnancy rates, and parameters that affected outcome were analyzed. Result(s): Only 3 of 174 patients failed to achieve blastocyst-stage ET. The mean blastocyst development rate was 48%. The ongoing pregnancy rate was 66.3% per oocyte retrieval, with a mean (±SE) of 2.2 ± 0.05 blastocysts transferred and an implantation rate of 48% per blastocyst …