作者
Didier Ménard, Nimol Khim, Johann Beghain, Ayola A Adegnika, Mohammad Shafiul-Alam, Olukemi Amodu, Ghulam Rahim-Awab, Céline Barnadas, Antoine Berry, Yap Boum, Maria D Bustos, Jun Cao, Jun-Hu Chen, Louis Collet, Liwang Cui, Garib-Das Thakur, Alioune Dieye, Djibrine Djallé, Monique A Dorkenoo, Carole E Eboumbou-Moukoko, Fe-Esperanza-Caridad J Espino, Thierry Fandeur, Maria-Fatima Ferreira-Da-Cruz, Abebe A Fola, Hans-Peter Fuehrer, Abdillahi M Hassan, Socrates Herrera, Bouasy Hongvanthong, Sandrine Houzé, Maman L Ibrahim, Mohammad Jahirul-Karim, Lubin Jiang, Shigeyuki Kano, Wasif Ali-Khan, Maniphone Khanthavong, Peter G Kremsner, Marcus Lacerda, Rithea Leang, Mindy Leelawong, Mei Li, Khin Lin, Jean-Baptiste Mazarati, Sandie Ménard, Isabelle Morlais, Hypolite Muhindo-Mavoko, Lise Musset, Kesara Na-Bangchang, Michael Nambozi, Karamoko Niaré, Harald Noedl, Jean-Bosco Ouédraogo, Dylan R Pillai, Bruno Pradines, Bui Quang-Phuc, Michael Ramharter, Milijaona Randrianarivelojosia, Jetsumon Sattabongkot, Abdiqani Sheikh-Omar, Kigbafori D Silué, Sodiomon B Sirima, Colin Sutherland, Din Syafruddin, Rachida Tahar, Lin-Hua Tang, Offianan A Touré, Patrick Tshibangu-Wa-Tshibangu, Inès Vigan-Womas, Marian Warsame, Lyndes Wini, Sedigheh Zakeri, Saorin Kim, Rotha Eam, Laura Berne, Chanra Khean, Sophy Chy, Malen Ken, Kaknika Loch, Lydie Canier, Valentine Duru, Eric Legrand, Jean-Christophe Barale, Barbara Stokes, Judith Straimer, Benoit Witkowski, David A Fidock, Christophe Rogier, Pascal Ringwald, Frederic Ariey, Odile Mercereau-Puijalon
发表日期
2016/6/23
期刊
New England Journal of Medicine
卷号
374
期号
25
页码范围
2453-2464
出版商
Massachusetts Medical Society
简介
Background
Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. falciparum gene encoding kelch (K13)–propeller domains are the major determinant of resistance has provided opportunities for monitoring such resistance on a global scale.
Methods
We analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel sites used for nationwide surveillance of antimalarial resistance. We evaluated the emergence and dissemination of mutations by haplotyping neighboring loci.
Results
We identified 108 nonsynonymous K13 mutations, which showed marked geographic disparity in their frequency and distribution. In Asia, 36.5% of the …
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D Ménard, N Khim, J Beghain, AA Adegnika… - New England Journal of Medicine, 2016