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In this study we show that benzo[ a ]pyrene (B[ a ]P) and the cyclopenta polycyclic aromatic hydrocarbons (CP-PAH) cyclopenta[ c , d ]pyrene (CPP), benz[ j ]aceanthrylene (B[ j ]A) and benz[ l ]aceanthrylene (B[ l ]A) induce apoptosis in Hepa1c1c7 cells, as measured by fluorescence microscopy and flow cytometry. The compounds induced formation of the active form of caspase-3, cleavage of its intracellular substrate, poly(ADP-ribose)polymerase (PARP), and DNA fragmentation. B[ j ]A was found to be the most potent in inducing apoptosis, followed by B[ a ]P, CPP and B[ l ]A. All compounds increased expression of CYP1A1 with relative potencies B[ j ]A > B[ a ]P ≫ CPP > B[ l ]A, corresponding well with their relative …