作者
J Øvrevik, VM Arlt, E Øya, E Nagy, S Mollerup, DH Phillips, M Låg, JA Holme
发表日期
2010/2/1
期刊
Toxicology and applied pharmacology
卷号
242
期号
3
页码范围
270-280
出版商
Academic Press
简介
Nitro-polycyclic aromatic hydrocarbons (nitro-PAHs) are found in diesel exhaust and air pollution particles. Along with other PAHs, many nitro-PAHs possess mutagenic and carcinogenic properties, but their effects on pro-inflammatory processes and cell death are less known. In the present study we examined the effects of 1-nitropyrene (1-NP), 3-nitrofluoranthene (3-NF) and 3-nitrobenzanthrone (3-NBA) and their corresponding amino forms, 1-AP, 3-AF and 3-ABA, in human bronchial epithelial BEAS-2B cells. The effects of the different nitro- and amino-PAHs were compared to the well-characterized PAH benzo[a]pyrene (B[a]P). Expression of 17 cytokine and chemokine genes, measured by real-time PCR, showed that 1-NP and 3-NF induced a completely different cytokine/chemokine gene expression pattern to that of their amino analogues. 1-NP/3-NF-induced responses were dominated by maximum effects on …
学术搜索中的文章
J Øvrevik, VM Arlt, E Øya, E Nagy, S Mollerup… - Toxicology and applied pharmacology, 2010