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The overall goal of this investigation was to produce nano-silica particles from white sandstone and control Cd (II) pollution from various aqueous matrixes. The generated nanoparticles have spherical morphology with a surface area of 298.71 m 2/g and a size of 30–40 nm. Based on the ANOVA findings, pH, temperature, nano-adsorbent quantity, initial cadmium concentration, and contact time parameters were effective (p-value< 0.05) in the Cd (II) adsorption process. The experimental results had a good agreement with the Freundlich model. According to response surface methodology data, the maximum efficiency (98.74%) of cadmium elimination by nano-silica obtained at a temperature of 25° C, Cd (II) content of 5 mg/L, contact time of 10 min, nano-silica dose of 0.67 g/L, and pH of 6.14. The maximum Cd (II) attraction onto white sandstone and nano-silica was 42.97 mg/g and 55.13 mg/g, respectively. The …