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High reactivity, reliable properties and positive environmental impacts of sepiolite clay in environment make it an important adsorbent for soil and water applications. Present review critically evaluates the applications of sepiolite in contaminated soils to adsorb toxic metals with an emphasis on cadmium (Cd) and lead (Pb). Research data has been compiled from about 140 publications reporting lab simulation studies, greenhouse experiments, and field trials. First section of this review describes the properties of sepiolite due to their role in dictating the efficiency of this mineral. In the next sections, we evaluate research advancements on the use of sepiolite for soil decontamination with a brief description about the underlying mechanisms. The properties and remediation efficiency of sepiolite can be tuned by its modification by physical or chemical strategies. In addition to its prominent metal adsorption capacity …