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The motivational effects of dopamine (DA) D1 receptor blockade and its influence on the motivational effects of amphetamine (1.0 mg/kg sc), morphine (1.0 mg/kg sc) and lithium (40 mg/kg sc) were studied in a place-conditioning paradigm. Drugs tested were two potent D1 receptor antagonists, SCH 23390 and SCH 39166, that differ in the poor affinity of the latter for 5-HT2 receptors, and SCH 23388, the inactive enantiomer of SCH 23390. SCH 23390 and SCH 39166, at low doses (12.5 and 25 [mu] g/kg sc), paired for 30 min with one compartment, elicited place aversion. Higher doses of the D1 antagonists or pairing for 60 min with one compartment failed to elicit place aversion. SCH 39166 (50 [mu] g/kg sc) paired with both compartments completely prevented the place-aversion elicited by SCH 23390 (12.5 [mu] g/kg sc), SCH 23390 and SCH 39166 at low doses (12.5 and 25 [mu] g/kg sc respectively), paired with …