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Maximizing surgical resection of medulloblastoma (MB) impacts overall survival; nevertheless, surgical resection remains a challenge since the infiltrative behavior of this tumor. Several dyes have been tested for improving tumor visualization; however, few reports with different protocols of fluorophores utilization and with inconstant results are available. Hence, we report our experience with sodium fluorescein (SF) in MB surgery, aiming to assess the role of this technique on extent of resection (EOR). Furthermore, we performed a literature review on this topic.

Fluorescence characteristics, EOR, and clinical outcome were analyzed in 9 consecutively operated MB patients. A comprehensive literature search and review for English-language articles concerning fluorescein application in MB has been conducted.

In our cohort, no side effect related to fluorescein occurred; all tumors …