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This article aims to provide detailed information on Malaysian plants used for treating inflammation. An extensive search on electronic databases including PubMed, Google Scholar, Scopus, and ScienceDirect and conference papers was done to find relevant articles on anti‐inflammatory activity of Malaysian medicinal plants. The keyword search terms used were “inflammation,” “Malaysia,” “medicinal plants,” “mechanisms,” “in vitro,” and “in vivo.” As a result, 96 articles on anti‐inflammatory activity of Malaysian medicinal plants were found and further reviewed. Forty‐six (46) plants (in vitro) and 30 plants (in vivo) have been identified to possess anti‐inflammatory activity where two plants, Melicope ptelefolia (Tenggek burung) and Portulaca oleracea (Gelang pasir), were reported to have the strongest anti‐inflammatory activity of more than 90% at a concentration of 250 µg/ml. It was showed that the activity was …