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Background . We obtained estimates of the incidence of tuberculosis (TB) among patients receiving HAART and identified determinants of the incidence.

Methods . We analyzed the incidence of TB during the first 3 years after initiation of HAART among 17,142 treatment-naive, AIDS-free persons starting HAART who were enrolled in 12 cohorts from Europe and North America. We used univariable and multivariable Poisson regression models to identify factors associated with the incidence.

Results . During the first 3 years (36,906 person-years), 173 patients developed TB (incidence, 4.69 cases per 1000 person-years). In multivariable analysis, the incidence rate was lower for men who have sex with men, compared with injection drug users (relative rate, 2.46; 95% confidence interval [CI], 1.51–4.01), heterosexuals (relative rate, 2.42; 95% CI, 1.64–3 …