作者
Erin C Berthold, Shyam H Kamble, Siva Rama Raju Kanumuri, Michelle A Kuntz, Alexandria S Senetra, Yi-Hua Chiang, Lance R McMahon, Christopher R McCurdy, Abhisheak Sharma
发表日期
2023/7
期刊
European Journal of Drug Metabolism and Pharmacokinetics
卷号
48
期号
4
页码范围
427-435
出版商
Springer International Publishing
简介
Background and Objectives
A wide variety of products containing cannabidiol (CBD) are available on the commercial market. One of the most common products, CBD oil, is administered to self-treat a variety of conditions. These oils are available as CBD isolate, broad-spectrum [all terpenes and minor cannabinoids except Δ-9-tetrahydrocannabinol (THC)], or full-spectrum (all terpenes and minor cannabinoids with THC < 0.3% dried weight) products. A systematic pharmacokinetic study was performed to determine whether there are differences in the pharmacokinetic parameters and systemic exposure of CBD after oral dosing as an isolate, broad-spectrum, or full-spectrum product.
Methods
Male and female Sprague Dawley rats were treated with a single, equivalent oral dose of CBD delivered as isolate, broad-spectrum, or full-spectrum product. An additional study using an in-house preparation of CBD isolate plus …
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EC Berthold, SH Kamble, SRR Kanumuri, MA Kuntz… - European Journal of Drug Metabolism and …, 2023