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We will evaluate the efficacy and safety of Melatonin, compared to the standard therapeutic regimen on clinical symptoms and serum inflammatory parameters in patients with confirmed COVID-19, who are moderately ill.

This is a single-center, randomized, double-blind, placebo-controlled clinical trial with a parallel-group design conducted at Shahid Mohammadi Hospital, Bandar Abbas, Iran.

All patients admitted to Severe Acute Respiratory Syndrome Departments of Shahid Mohammadi Hospital, Bandar Abbas, Iran will be screened for the following criteria.

Inclusion criteria:

1. Age ≥20 years

2. Confirmed SARS-CoV-2 diagnosis (positive polymerase chain reaction).

3. Moderate COVID-19 pneumonia (via computed tomography and or X-ray imaging), requiring hospitalization.

4. Hospitalized ≤48 hours.

5. Signing informed consent and willingness of the participant to …