作者
Najmeh Showraki, Maryam Mardani, Masoumeh Emamghoreishi, Azadeh Andishe-Tadbir, Alireza Aram, Peiman Mehriar, Mahmoud Omidi, Masood Sepehrimanesh, Omid Koohi-Hosseinabadi, Nader Tanideh
发表日期
2016/12
期刊
Journal of Dentistry
卷号
17
期号
4
页码范围
334
出版商
Shiraz University of Medical Sciences
简介
Purpose:
This study aimed to evaluate the healing effects of olive leaf extract on 5-fluorouracil-induced OM in golden hamster.
Materials and Method:
OM was induced in 63 male golden hamsters by the combination of 5-fluorouracil injections (days 0, 5 and 10) and the abrasion of the cheek pouch (days 3 and 4). On day 12, hamsters were received topical olive leaf extract ointment, base of ointment, or no treatment (control) for 5 days. Histopathology evaluations, blood examinations, and tissue malondialdehyde level measurement were performed 1, 3 and 5 days after treatments.
Results:
Histopathology score and tissue malondialdehyde level were significantly lower in olive leaf extract treated group in comparison with control and base groups (p= 0.000). Significant decreases in white blood cell, hemoglobin, hematocrit, and mean corpuscular volume and an increase in mean corpuscular hemoglobin concentration …
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N Showraki, M Mardani, M Emamghoreishi… - Journal of Dentistry, 2016