作者
David A Dorward, Clark D Russell, In Hwa Um, Mustafa Elshani, Stuart D Armstrong, Rebekah Penrice-Randal, Tracey Millar, Chris EB Lerpiniere, Giulia Tagliavini, Catherine S Hartley, Nadine P Randle, Naomi N Gachanja, Philippe MD Potey, Xiaofeng Dong, Alison M Anderson, Victoria L Campbell, Alasdair J Duguid, Wael Al Qsous, Ralph BouHaidar, J Kenneth Baillie, Kevin Dhaliwal, William A Wallace, Christopher OC Bellamy, Sandrine Prost, Colin Smith, Julian A Hiscox, David J Harrison, Christopher D Lucas, ICECAP consortium
发表日期
2020/11/20
期刊
American Journal of Respiratory and Critical Care Medicine
期号
ja
简介
Rationale: In life-threatening coronavirus disease (COVID-19), corticosteroids reduce mortality, suggesting that immune responses have a causal role in death. Whether this deleterious inflammation is primarily a direct reaction to the presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or an independent immunopathologic process is unknown.
Objectives: To determine SARS-CoV-2 organotropism and organ-specific inflammatory responses and the relationships among viral presence, inflammation, and organ injury.
Methods: Tissue was acquired from 11 detailed postmortem examinations. SARS-CoV-2 organotropism was mapped by using multiplex PCR and sequencing, with cellular resolution achieved by in situ viral S (spike) protein detection. Histologic evidence of inflammation was quantified from 37 anatomic sites, and the pulmonary immune response was characterized by using …
学术搜索中的文章
DA Dorward, CD Russell, IH Um, M Elshani… - American journal of respiratory and critical care …, 2021