作者
Marco Metra, Loredana Covolo, Natalia Pezzali, Valerio Zacà, Silvia Bugatti, Carlo Lombardi, Luca Bettari, Alessia Romeo, Umberto Gelatti, Raffaele Giubbini, Francesco Donato, Livio Dei Cas
发表日期
2010/2
期刊
Cardiovascular drugs and therapy
卷号
24
页码范围
49-60
出版商
Springer US
简介
Background
Beta-blockers are mainstay of current treatment of heart failure (HF). Beta-adrenergic receptors (AR) single nucleotide gene polymorphisms (SNPs) may influence the sensitivity and density of beta-AR. We assessed the relation between three common beta-AR SNPs and the response to carvedilol administration.
Methods and Results
We studied 183 consecutive patients with chronic HF due to ischemic or nonischemic cardiomyopathy, a LV ejection fraction (LVEF) ≤ 0.35, not previously treated with beta-blockers. Each patient underwent gated-SPECT radionuclide ventriculography, cardiopulmonary exercise testing and invasive hemodynamic monitoring at baseline and after 12 months of carvedilol administration at maintenance dosages. The beta1-AR gene Arg389Gly and the beta2-AR gene Arg16Gly SNPs were not related to the …
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M Metra, L Covolo, N Pezzali, V Zacà, S Bugatti… - Cardiovascular drugs and therapy, 2010