作者
Paul Young, Michael Bailey, Richard Beasley, Seton Henderson, Diane Mackle, Colin McArthur, Shay McGuinness, Jan Mehrtens, John Myburgh, Alex Psirides, Sumeet Reddy, Rinaldo Bellomo
发表日期
2015/10/27
期刊
Jama
卷号
314
期号
16
页码范围
1701-1710
出版商
American Medical Association
简介
Importance
Saline (0.9% sodium chloride) is the most commonly administered intravenous fluid; however, its use may be associated with acute kidney injury (AKI) and increased mortality.
Objective
To determine the effect of a buffered crystalloid compared with saline on renal complications in patients admitted to the intensive care unit (ICU).
Design and Setting
Double-blind, cluster randomized, double-crossover trial conducted in 4 ICUs in New Zealand from April 2014 through October 2014. Three ICUs were general medical and surgical ICUs; 1 ICU had a predominance of cardiothoracic and vascular surgical patients.
Participants
All patients admitted to the ICU requiring crystalloid fluid therapy were eligible for inclusion. Patients with established AKI requiring renal replacement therapy (RRT) were excluded. All 2278 eligible patients were enrolled; 1152 of 1162 patients (99.1%) receiving buffered crystalloid and …
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P Young, M Bailey, R Beasley, S Henderson, D Mackle… - Jama, 2015
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