作者
Belen Gutierrez-Gutierrez, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Benito Almirante, Luis Martinez-Martinez, Antonio Oliver, Esther Calbo, Carmen Pena, Murat Akova, Johann Pitout, Julia Origüen, Vicente Pintado, Elisa Garcia-Vazquez, Oriol Gasch, Axel Hamprecht, Nuria Prim, Mario Tumbarello, German Bou, Pierluigi Viale, Evelina Tacconelli, Manel Almela, Federico Perez, Helen Giamarellou, José Miguel Cisneros, Mitchell J Schwaber, Mario Venditti, Warren Lowman, Joaquin Bermejo, Po-Ren Hsueh, Marta Mora-Rillo, Irene Gracia-Ahulfinger, Alvaro Pascual, Jesus Rodriguez-Bano, REIPI/ESGBIS/INCREMENT Group, J Gálvez, M de Cueto, E Salamanca, M Falcone, A Russo, G Daikos, I Karaiskos, EM Trecarichi, AR Losito, DL Paterson, A Hernández, J Gómez, E Roilides, E Iosifidis, Y Doi, FF Tuon, F Navarro, B Mirelis, R San Juan, M Fernández-Ruiz, N Larrosa, M Puig, J Molina, V González, V Rucci, E Ruiz de Gopegui, CI Marinescu, MC Fariñas, ME Cano, M Gozalo, JR Paño-Pardo, C Navarro-San Francisco, S Gómez-Zorrilla, F Tubau, S Pournaras, A Tsakris, O Zarkotou, ÖK Azap, M Souli, A Antoniadou, G Poulakou, D Virmani, I Machuca, E Pérez-Nadales, J Torre-Cisneros, Ö Helvaci, AO Sahin, R Cantón, P Ruiz, M Bartoletti, M Giannella, F Riemenschneider, C Badia, M Xercavins, D Fontanals, E Jové
发表日期
2016/6/1
期刊
Journal of Antimicrobial Chemotherapy
卷号
71
期号
6
页码范围
1672-1680
出版商
Oxford University Press
简介
Objectives
Data about the efficacy of ertapenem for the treatment of bloodstream infections (BSI) due to ESBL-producing Enterobacteriaceae (ESBL-E) are limited. We compared the clinical efficacy of ertapenem and other carbapenems in monomicrobial BSI due to ESBL-E.
Methods
A multinational retrospective cohort study (INCREMENT project) was performed (ClinicalTrials.gov identifier: NCT01764490). Patients given monotherapy with ertapenem or other carbapenems were compared. Empirical and targeted therapies were analysed. Propensity scores were used to control for confounding; sensitivity analyses were performed in subgroups. The outcome variables were cure/improvement rate at day 14 and all-cause 30 day mortality.
Results
The empirical therapy cohort (ETC) and the targeted therapy cohort (TTC) included 195 and 509 patients …
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B Gutierrez-Gutierrez, RA Bonomo, Y Carmeli… - Journal of Antimicrobial Chemotherapy, 2016