作者
Belén Gutiérrez-Gutiérrez, Salvador Perez-Galera, Elena Salamanca, Marina De Cueto, Esther Calbo, Benito Almirante, Pierluigi Viale, Antonio Oliver, Vicente Pintado, Oriol Gasch, Luis Martinez-Martinez, Johann Pitout, Murat Akova, Carmen Pena, Jose Molina, Alicia Hernandez, Mario Venditti, Nuria Prim, Julia Origüen, German Bou, Evelina Tacconelli, Mario Tumbarello, Axel Hamprecht, Helen Giamarellou, Manel Almela, Federico Perez, Mitchell J Schwaber, Joaquin Bermejo, Warren Lowman, Po-Ren Hsueh, Marta Mora-Rillo, Clara Natera, Maria Souli, Robert A Bonomo, Yehuda Carmeli, David L Paterson, Alvaro Pascual, Jesus Rodriguez-Bano
发表日期
2016/7
期刊
Antimicrobial agents and chemotherapy
卷号
60
期号
7
页码范围
4159-4169
出版商
American Society for Microbiology
简介
The spread of extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae (ESBL-E) is leading to increased carbapenem consumption. Alternatives to carbapenems need to be investigated. We investigated whether β-lactam/β-lactamase inhibitor (BLBLI) combinations are as effective as carbapenems in the treatment of bloodstream infections (BSI) due to ESBL-E. A multinational, retrospective cohort study was performed. Patients with monomicrobial BSI due to ESBL-E were studied; specific criteria were applied for inclusion of patients in the empirical-therapy (ET) cohort (ETC; 365 patients), targeted-therapy (TT) cohort (TTC; 601 patients), and global cohort (GC; 627 patients). The main outcome variables were cure/improvement rate at day 14 and all-cause 30-day mortality. Multivariate analysis, propensity scores (PS), and sensitivity analyses were used to control for confounding. The cure …
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B Gutiérrez-Gutiérrez, S Perez-Galera, E Salamanca… - Antimicrobial agents and chemotherapy, 2016