作者
A Russo, M Falcone, B Gutiérrez-Gutiérrez, E Calbo, B Almirante, PL Viale, A Oliver, P Ruiz-Garbajosa, O Gasch, M Gozalo, J Pitout, M Akova, C Peña, JM Cisneros, A Hernández-Torres, A Farcomeni, N Prim, J Origüen, G Bou, E Tacconelli, M Tumbarello, A Hamprecht, I Karaiskos, C de la Calle, F Pérez, MJ Schwaber, J Bermejo, W Lowman, P-R Hsueh, M Mora-Rillo, J Rodriguez-Gomez, M Souli, RA Bonomo, DL Paterson, Y Carmeli, A Pascual, J Rodríguez-Baño, M Venditti
发表日期
2018/11/1
期刊
International journal of antimicrobial agents
卷号
52
期号
5
页码范围
577-585
出版商
Elsevier
简介
Purpose
There are few data in the literature regarding sepsis or septic shock due to extended-spectrum β-lactamases (ESBL)-producing Enterobacteriaceae (E). The aim of this study was to assess predictors of outcome in septic patients with bloodstream infection (BSI) caused by ESBL-E.
Methods
Patients with severe sepsis or septic shock and BSI due to ESBL-E were selected from the INCREMENT database. The primary endpoint of the study was the evaluation of predictors of outcome after 30 days from development of severe sepsis or septic shock due to ESBL-E infection. Three cohorts were created for analysis: global, empirical-therapy and targeted-therapy cohorts.
Results
367 septic patients were analysed. Overall mortality was 43.9% at 30 days. Escherichia coli (62.4%) and Klebsiella pneumoniae (27.2%) were the most frequent isolates. β-lactam/β-lactamase inhibitor (BLBLI) combinations were the most …
学术搜索中的文章
A Russo, M Falcone, B Gutiérrez-Gutiérrez, E Calbo… - International journal of antimicrobial agents, 2018