作者
Ingrid Meulenbelt, Josine L Min, Steffan Bos, Naghmeh Riyazi, Jeanine J Houwing-Duistermaat, Henk-Jan van der Wijk, Herman M Kroon, Masahiro Nakajima, Shiro Ikegawa, Andre G Uitterlinden, Joyce BJ van Meurs, Wendy M van der Deure, Theo J Visser, Albert B Seymour, Nico Lakenberg, Ruud van der Breggen, Dennis Kremer, Cornelia M van Duijn, Margreet Kloppenburg, John Loughlin, P Eline Slagboom
发表日期
2008/6/15
期刊
Human molecular genetics
卷号
17
期号
12
页码范围
1867-1875
出版商
Oxford University Press
简介
Osteoarthritis [MIM 165720] is a common late-onset articular joint disease for which no pharmaceutical intervention is available to attenuate the cartilage degeneration. To identify a new osteoarthritis susceptibility locus, a genome-wide linkage scan and combined linkage association analysis were applied to 179 affected siblings and four trios with generalized osteoarthritis (The GARP study). We tested, for confirmation by association, 1478 subjects who required joint replacement and 734 controls in a UK population. Additional replication was tested in 1582 population-based females from the Rotterdam study that contained 94 cases with defined hip osteoarthritis and in 267 Japanese females with symptomatic hip osteoarthritis and 465 controls. Suggested evidence for linkage in the GARP study was observed on chromosome 14q32.11 (log of odds = 3.03, P = 1.9×10−4). Genotyping tagging single-nucleotide …
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I Meulenbelt, JL Min, S Bos, N Riyazi… - Human molecular genetics, 2008