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Mentha piperita essential oil was bactericidal in order of E. coli> S. aureus> Pseudomonas aeruginosa> S. faecalis> Klebsiella pneumoniae. The oil with total phenolics of 89.43±0.58 µg GAE/mg had 63.82±0.05% DPPH inhibition activity with an IC 50= 3.9 µg/ml. Lipid peroxidation inhibition was comparable to BHT and BHA. A 127% hike was noted in serum ferric-reducing antioxidant power. There was 38.3% decrease in WBCs count, while platelet count showed increased levels of 214.12%. Significant decrease in uric acid level and cholesterol/HDL and LDL/HDL ratios were recorded. The volatile oil displayed high cytotoxic action toward the human tumor cell line. The results of this study deserve attention with regard to antioxidative and possible anti-neoplastic chemotherapy that form a basis for future research. The essential oil of mint may be exploited as a natural source of bioactive phytopchemicals bearing …