查看文章

Acquired immune deficiency syndrome (AIDS) is characterized by opportunistic infections and by ‘opportunistic neoplasms’ (for example, Kaposi's sarcoma)¹. Persistent generalized lymphadenopathy (PGL) is epidemiologically associated with AIDS, especially in male homosexuals. A subset of T lymphocytes positive for the CD4 antigen² (also termed T4 antigen), is depleted in AIDS and PGL patients. A retrovirus found in T-cell cultures from these patients^3–5 is strongly implicated in the aetiology of AIDS because of the high frequency of isolation⁴ and the prevalence of specific antibodies^6–8 in the patients. Here we have detected cell-surface receptors for the AIDS retrovirus (human T-cell leukaemia virus-III (HTLV-III) and lymphadenopathy-associated virus-1 (LAV-1) isolates) by testing the susceptibility of cells to infection with pseudotypes of vesicular stomatitis virus bearing retroviral envelope antigens, and by …