作者
Laurent Mandelbrot, Roland Tubiana, Jerome Le Chenadec, Catherine Dollfus, Albert Faye, Emmanuelle Pannier, Sophie Matheron, Marie-Aude Khuong, Valerie Garrait, Veronique Reliquet, Alain Devidas, Alain Berrebi, Christine Allisy, Christophe Elleau, Cedric Arvieux, Christine Rouzioux, Josiane Warszawski, Stéphane Blanche, ANRS-EPF Study Group, Laurent Mandelbrot, Catherine Crenn-Hebert, Corinne Floch-Tudal, Fabienne Mazy, Marine Joras, Françoise Meier, Emmanuel Mortier, Pierre-François Ceccaldi, Maïa Banige, Agnès Villemant Uludag, Virginie Zarouk, Agnès Lefort, Gilles Hittinger, Jean-Marc Chamouilli, Christian Burle, Alain Lafeuillade, Marie Medus, Germaine Bachelard, Joëlle Dendale-Nguyen, Thomas Guimard, Karine Guimard, Jean-Pierre Brossier, Philippe Perré, Jean-Luc Esnault, Olivier Bollengier Stragier, Sophie Leautez-Nainville, Sandrine-Anne Martha, Benoît Martha, Elise Maurel, Michel Françoise, Muriel Barat, Patricia Murger, Mahfoud Rouha, Philippe Lumbroso, Alain Checoury, Pascale Perfezou, Gilles Blondin, Séverine Ansart, Luc De Saint Martin, Philippe Le Moine, Corinne Daniel, Christian Calvez, Emmanuelle Boutard, Cédric Arvieux, Estelle Bauville, Christelle Dupre, Yves Poinsignon, Anne Grelier, Gaetane Mousset, Corinne Cudeville, Mathilde Niault, Isabelle Belzic, Philippe Moreau, Marie-Françoise Le Coz, Odile Luycx Vaillant, Virginie Vitrat, Didier Tardif, Jacques Gaillat, Anne Vanderbergh, Suzanne Braig, Marion Dehlinger-Paul, Khaled Mohamed, Brigitte Heller-Roussin, Cécile Winter, Ghislaine Firtion, Emmanuelle Pannier, Myriam Costa, Odile Launay, Dominique Salmon Ceron, Sophie Matheron, Mandovi Rajguru, Neila Elaoun, Lahcene Allal, Elie Azria, Agnès Bourgeois Moine, Valérie Garrait, Isabelle Hau, Claudine Touboul, Lanto Ratsimbazafy, Christiane Kommé, Brigitte Elharrar, Jean-Marc Labaune, Laurent Cotte, René-Charles Rudigoz, Christophe Elleau, Camille Runel-Belliard, Thierry Pistone, Blandine Muanza, Elisabeth Broustal, Marc Duval-Arnould, Bénédicte Carpentier, Etienne Dienga, MariaLuisa Partisani, Natacha Entz-Werle, Eric David, David Rey, Hervé Seaume, Sarah Ducrocq, Philippe Bailly-Salin, Joëlle Tricoire, Alain Berrebi, Claudine Cayla, Anne Chacé, Isabelle Metheron, Anne Boutemy, Didier Armangaud, Sophie Couderc, Corinne Routier, Alain Alissa, Elisabeth Questiaux, Ahmed Zakaria, Hélène Dauphin, Céline Goissen, Marie Belloy, Jean-Luc Delassus, MariaLuisa Partisani, Christine Cheneau, Jean-Marie Lang, Dominique Brault, Christine Allisy, Marie-Gisèle Lebrette, Lise Selleret, François Hervé, Pascal Bolot, Marie-Aude Khuong-Josses, Dieudoné Ekoukou, Stéphane Bounan, Stéphane Blanche, Delphine Lemercier, Pierre Frange, Florence Veber
发表日期
2015/12/1
期刊
Clinical Infectious Diseases
卷号
61
期号
11
页码范围
1715-1725
出版商
Oxford University Press
简介
Background. The efficacy of preventing perinatal transmission (PT) of human immunodeficiency virus type 1 (HIV-1) depends on both viral load (VL) and treatment duration. The objective of this study was to determine whether initiating highly active antiretroviral therapy (ART) before conception has the potential to eliminate PT.
Methods. A total of 8075 HIV-infected mother/infant pairs included from 2000 to 2011 in the national prospective multicenter French Perinatal Cohort (ANRS-EPF) received ART, delivered live-born children with determined HIV infection status, and did not breastfeed. PT was analyzed according to maternal VL at delivery and timing of ART initiation.
Results. The overall rate of PT was 0.7% (56 of 8075). No transmission occurred among 2651 infants born to women who were receiving ART before conception, continued …
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L Mandelbrot, R Tubiana, J Le Chenadec, C Dollfus… - Clinical Infectious Diseases, 2015