作者
Celal Salcini, Belkis Atasever-Arslan, Gulin Sunter, Hazal Gur, Fatma Busra Isik, Cemil Can Saylan, Ayse Destina Yalcin
发表日期
2016
期刊
The Tohoku Journal of Experimental Medicine
卷号
239
期号
1
页码范围
73-79
简介
Diabetic polyneuropathy is the most common neurologic complication of diabetes mellitus. Underlying mechanisms of diabetic polyneuropathy are related to various metabolic and inflammatory pathways. Pentraxin 3 (PTX3) is an acute phase protein that is produced locally at the inflammatory sites by several cell types. Thioredoxin binding protein 2 (TBP2) is a thioredoxin regulator involved in intracellular energy pathways and cell growth. We measured the plasma levels of PTX3 and TBP2 in type 2 diabetic patients (n= 27) with pain complaints and compared their levels with those of healthy age-and sex-matched subjects (n= 24). Moreover, the diabetic patients were divided into two groups using the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain scale: patients with nociceptive pain that is caused by tissue damage and patients with neuropathic pain that is caused by nerve damage. Patients with LANSS scores of< 12 were considered to have nocicceptive pain (n= 15), while patients with LANSS scores of≥ 12 were considered to have neuropathic pain (n= 12). We found that PTX3 levels were significantly higher in diabetic patients compared to controls (p= 0.03), but there was no significant difference in the TBP2 levels. Importantly, patients with nociceptive pain had significantly higher PTX3 levels compared to patients with neuropathic pain (p< 0.05). Thus, plasma PTX3 levels can be helpful for discrimination of nociceptive pain from neuropathic pain in diabetic patients. We propose that PTX3 may contribute to the onset of nociceptive pain.
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C Salcini, B Atasever-Arslan, G Sunter, H Gur, FB Isik… - The Tohoku Journal of Experimental Medicine, 2016