作者
Belkis Atasever, Nesrin Zeynep Ertan, Serap Erdem-Kuruca, Zeynep Karakas
发表日期
2006/1/1
期刊
Pediatric hematology and oncology
卷号
23
期号
3
页码范围
187-197
出版商
Taylor & Francis
简介
In this study, the in vitro effects of vitamin C and selenium on natural killer (NK) cell activity of β-thalassemia major patients was investigated. At first, significant decreased NK activity was found at E:T ratios of 1:1, 5:1, and 10:1 in whole thalassemia patients. Low-dose selenium treatment enhanced NK activity in patients but there was no change in the control group. High-dose selenium decreased NK activity significantly in splenectomized patients. Different doses vitamin C enhanced NK activity significantly in both splenectomized and unsplenectomized patients. According to these results, selenium dosage should be arranged carefully in thalassemia patients, whereas vitamin C can be used confidently.
学术搜索中的文章
B Atasever, NZ Ertan, S Erdem-Kuruca, Z Karakas - Pediatric hematology and oncology, 2006