作者
Claudia Omarini, Giorgia Guaitoli, Silvia Noventa, Alessia Andreotti, Anna Gambini, E Palma, Simona Papi, Giovanni Tazzioli, Sara Balduzzi, Massimo Dominici, Stefano Cascinu, Federico Piacentini
发表日期
2017/4/1
期刊
European Journal of Surgical Oncology (EJSO)
卷号
43
期号
4
页码范围
613-618
出版商
WB Saunders
简介
Background
The optimal time interval between the end of neoadjuvant systemic therapy (NST) and breast surgery is still unclear. It is not known if a delay in surgery might influence the benefit of primary chemotherapy. The aim of this study is to evaluate the relationship between time to surgery (TTS) and survival outcomes.
Patients and methods
According to TTS, women with diagnosis of BC treated with NST were divided into two cohorts: group A = 21 days or fewer and group B = longer than 21 days. OS and RFS were estimated and compared according to TTS and known prognostic factors.
Results
A total of 319 patients were included in the study: 61 in group A and 258 in group B. Median TTS was 34 days. No association between clinical stage, nuclear grade, type of chemotherapy, type of surgery and TTS was detected. OS and RFS were significantly worse for group B compared with group A, with a hazard ratio of …
学术搜索中的文章
C Omarini, G Guaitoli, S Noventa, A Andreotti… - European Journal of Surgical Oncology (EJSO), 2017