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Medical implants are devices fabricated to replace, aid, or enhance some missing biological structure (Singh et al., 2020). These devices include catheters, stents, hip joints, intraocular lenses, and others. The implant surfaces are designed with biocompatible materials since they will be in direct contact with physiological fluids and tissues, such as titanium, silicone, bioactive glass, polymers, among others. In addition, the choice of the appropriate biomaterial is guided by the presence of desirable properties according to the claimed application (Ratner and Zhang, 2020). Surgery is the most common way to incorporate medical implants into the body, which involves inherent risks: bacterial infections, local swelling and induration, inadequate healing, triggering immune reactions, and other different possible complications (Major et al., 2015). The eventuality and intensity of these postoperative risks are higher in cases of immunosuppression caused by certain diseases or conditions, such as AIDS, cancer, diabetes, malnutrition, and certain genetic disorders (Madsen et al., 2021). In that sense, biomacromolecules are versatile to be configurated as release systems of therapeutic agents to health or significantly reduce those postoperative risks. This Research Topic collection covers the use of biomacromolecules systems applied to biomedical implants for the release of therapeutic agents. This collection of papers is formed of seven original research articles and one review article. Different interesting antibiotic drug delivery systems based on biomacromolecules were presented in this Research Topic. New proposes were physiochemically detailed …