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Several cellulosic substrates have been surface‐functionalized with cyclomaltoheptaose (β‐cyclodextrin, β‐CD) using citric acid as a crosslinker agent to obtain new surface‐modified materials able to release antiseptic molecules over a prolonged period, in view of their use in medical domain. Three different commercial cellulosic substrates were used, namely: (i) an uncoated paper, (ii) a crepe paper, and (iii) a medical bandage. They were successfully grafted by a crosslinked polymer consisting on β‐CD molecules as assessed by scanning electron microscopy and Fourier transform infrared spectroscopy analysis. Several time–temperature kinetic cycles were performed to reach the optimum curing parameters. The grafted and nongrafted samples were loaded with chlorhexidine digluconate (digCHX), a widely used antiseptic agent. The drug‐delivery kinetics of the encapsulated digCHX was carried out by …