作者
Syrine Dimassi, Nicolas Tabary, Feng Chai, Nicolas Blanchemain, Bernard Martel
发表日期
2018/12/15
来源
Carbohydrate polymers
卷号
202
页码范围
382-396
出版商
Elsevier
简介
From 20th century, chitosan, a natural polysaccharide, has received much attention for use in biomedical applications thanks to its remarkable properties, such as biodegradability, biocompatibility, hemostasis and antibacterial activity. Over the last decades, many researchers have attempted to generate new chitosan derivatives-based biomaterials though chemical modifications, especially through sulfonation or sulfation reactions in order to tailor the physicochemical and biochemical properties. Due to the presence of residual amino groups, the generated polyampholytic derivatives are characterized by convenient biological properties, such as antioxidation, antiviral activity, anticoagulation and bone regeneration, expanding their application scope. This paper provides an overview of the strategies used to chemically modify chitosan by introduction of sulfonate groups on chitosan backbone, focusing on various …
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S Dimassi, N Tabary, F Chai, N Blanchemain, B Martel - Carbohydrate polymers, 2018