作者
Daniel J Grint, Kevin Wing, Hamish P Gibbs, Stephen JW Evans, Elizabeth J Williamson, Krishnan Bhaskaran, Helen I McDonald, Alex J Walker, David Evans, George Hickman, Rohini Mathur, Anna Schultze, Christopher T Rentsch, John Tazare, Ian J Douglas, Helen J Curtis, Caroline E Morton, Sebastian CJ Bacon, Simon Davy, Brian MacKenna, Peter Inglesby, Richard Croker, John Parry, Frank Hester, Sam Harper, Nicholas J DeVito, William J Hulme, Christopher Bates, Jonathan Cockburn, Amir Mehrkar, Ben Goldacre, Rosalind M Eggo, Laurie Tomlinson
发表日期
2022
期刊
medRxiv
页码范围
2022.05. 03.22274602
出版商
Cold Spring Harbor Laboratory Press
简介
The SARS-CoV-2 Omicron variant is increasing in prevalence around the world. Accurate estimation of disease severity associated with Omicron is critical for pandemic planning. We found lower risk of accident and emergency (AE) attendance following SARS-CoV-2 infection with Omicron compared to Delta (HR: 0.39 (95% CI: 0.30 – 0.51; P<.0001). For AE attendances that lead to hospital admission, Omicron was associated with an 85% lower hazard compared with Delta (HR: 0.14 (95% CI: 0.09 – 0.24; P<.0001)).
Conflicts of Interests
Nothing to declare.
Funding statement
This work was supported by the Medical Research Council MR/V015737/1. TPP provided technical expertise and infrastructure within their data centre pro bono in the context of a national emergency. Rosalind Eggo is funded by HDR UK (grant: MR/S003975/1), MRC (grant: MC_PC 19065), NIHR (grant: NIHR200908).
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DJ Grint, K Wing, HP Gibbs, SJW Evans, E Williamson… - medRxiv, 2022